![]() ![]() There was no significant difference in the route of administration or dose between the patients with obesity and the patients without obesity. The definition of warfarin reversal of warfarin is correcting an international normalized ratio (INR) to ≤ 2.0 within 72 hours after phytonadione administration. In a single-center retrospective cohort study by Luc et al., they assessed the effectiveness of phytonadione to reverse warfarin in patients with obesity defined as a body mass index (BMI) ≥ 30 kg/m^2. IV 10 mg as soon as possible the IV infusion rate should not exceed 1 mg/minute.
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